![]() ![]() Dehydrocoumadin, two Di stereoisomer alcohols, 4′-, 6-, 7-, 8-, and 10-hydroxycoumadin are among the coumadin metabolites that have been discovered. The majority of the metabolites are expelled primarily in the urine, but also in the bile to a lesser proportion. The anticoagulant action of coumadin alcohols is quite low. ![]() Coumadin is metabolized stereo selectively by hepatic microsomal enzymes (cytochrome P-450) to inactive hydroxylated metabolites (predominant pathway) and reduced metabolites by reductases (coumadin alcohols). Coumadin is almost totally eliminated through metabolism. ![]()
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